منابع مشابه
Ccr5
Adipose tissue macrophage (ATM) accumulation through C-C motif chemokine receptor 2 (CCR2) and its ligand monocyte chemoattractant protein-1 (MCP-1) is considered pivotal in the development of insulin resistance. However, our new study has demonstrated that CCR5, a different CC chemokine receptor, plays an important role in the ATM recruitment and activation and subsequent development of insuli...
متن کاملThe frequency of CCR5 promoter polymorphisms and CCR5 32 mutation in Iranian populations
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pai...
متن کاملStructural and molecular interactions of CCR5 inhibitors with CCR5.
We have characterized the structural and molecular interactions of CC-chemokine receptor 5 (CCR5) with three CCR5 inhibitors active against R5 human immunodeficiency virus type 1 (HIV-1) including the potent in vitro and in vivo CCR5 inhibitor aplaviroc (AVC). The data obtained with saturation binding assays and structural analyses delineated the key interactions responsible for the binding of ...
متن کاملEffects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions.
BACKGROUND This study aimed to examine how CC chemokine receptor 5 (CCR5) inhibitors (aplaviroc [APL], TAK779 and maraviroc [MVC]) interact with CCR5 and affect its dynamics and physiological CC-chemokine-CCR5 interactions. METHODS A yellow fluorescent protein (YFP)-tagged CCR5-expressing U373-MAGI cell line was generated and a stable CCR5-expressing clonal population, (YFP)CCR5-UM16, was pre...
متن کاملCCR5 Inhibitors and HIV
In August of 2007, the Food and Drug Administration (fda) approved the first chemokine (c-c motif) receptor 5 (ccr5) inhibitor, maraviroc, for treatment-experienced patients infected with r5-using virus. In an effort to better educate physicians and patients about these new drugs, this article will review the available clinical data on ccr5 antagonists and discuss implications for clinical prac...
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ژورنال
عنوان ژورنال: Adipocyte
سال: 2013
ISSN: 2162-3945,2162-397X
DOI: 10.4161/adip.22420